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human SPTBN1 shRNA silencing AAV

Name 
AAV-h-SPTBN1-shRNA
Cat No 
shAAV-224291
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SPTBN1.

shAAV-224291
AAV-h-SPTBN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPTBN1 (spectrin beta, non-erythrocytic 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
beta-fodrin; beta-G spectrin; beta-II spectrin; beta-spectrin 2; beta-spectrin II; beta-spectrin non-erythrocytic 1; betaSpII; ELF; embryonic liver beta-fodrin; epididymis luminal protein 102; fodrin beta chain; HEL102; spectrin beta chain, brain 1; spectrin beta chain, non-erythrocytic 1; spectrin, non-erythroid beta chain 1; SPTB2
Description (eCommerce)
Beta spectrin (SPTBN1) is a subunit of the spectrin cytoskeletal scaffolding protein that links the plasma membrane to cytoskeletal actin and functions in cellular shape and organelle organization.
Description (Vector)
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6711
Gene Name (eCommerce)
spectrin beta, non-erythrocytic 1
Gene Name (Vector)
spectrin beta, non-erythrocytic 1
Gene Symbol
SPTBN1
HGNC ID
HGNC:11275
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6468
ORF Size (bp)
6468 bp
Protein Name (eCommerce)
Spectrin beta chain, non-erythrocytic 1
RefSeq ID
NM_003128
RefSeq Synonyms
NM_178313, NM_003128, BC137283, BC137282,
Research Areas
Axon Guidance,Cell Cycle,Cytoskeleton,Golgi Apparatus,Neurobiology,Signal Transduction,TGF-beta Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Beta spectrin (SPTBN1) is a subunit of the spectrin cytoskeletal scaffolding protein that links the plasma membrane to cytoskeletal actin and functions in cellular shape and organelle organization.
UniGene ID
Hs.705692
UniProt ID (eCommerce)
Q01082

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.