human SPINK5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SPINK5.
shAAV-224187
AAV-h-SPINK5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SPINK5 (serine peptidase inhibitor, Kazal type 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LEKTI; LETKI; NETS; NS; VAKTI
Description (Vector)
SPINK5 encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
11005
Gene Name (Vector)
serine peptidase inhibitor, Kazal type 5
Gene Symbol
SPINK5
HGNC ID
HGNC:15464
ORF Size (aa)
3192
ORF Size (bp)
3192 bp
RefSeq ID
NM_006846
RefSeq Synonyms
NM_006846, NM_001127699, NM_001127698, BC141545,
Species
human
UniGene ID
Hs.331555
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.