human SPG7 shRNA silencing AAV

Name
AAV-h-SPG7-shRNA

Cat No
shAAV-224163

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SPG7.

shAAV-224163

AAV-h-SPG7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPG7 (SPG7, paraplegin matrix AAA peptidase subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAR; CMAR; PGN; SPG5C

Description (Vector)

SPG7 encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7.

Gene ID

6687

Gene Name (Vector)

SPG7, paraplegin matrix AAA peptidase subunit

Gene Symbol

SPG7

HGNC ID

HGNC:11237

ORF Size (aa)

2388

ORF Size (bp)

2388 bp

RefSeq ID

NM_003119

RefSeq Synonyms

NM_199367, NM_003119, BC036104, BC007692,

Species

human

UniGene ID

Hs.185597

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.