human SPA17 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SPA17.
shAAV-224055
AAV-h-SPA17-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SPA17 (sperm autoantigenic protein 17). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CT22; SP17; SP17-1
Description (Vector)
SPA17 encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.
Gene ID
53340
Gene Name (Vector)
sperm autoantigenic protein 17
Gene Symbol
SPA17
HGNC ID
HGNC:11210
ORF Size (aa)
456
RefSeq ID
NM_017425
RefSeq Synonyms
NM_017425, BC032457,
Species
human
UniGene ID
Hs.286233
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.