human SOST shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SOST.
shAAV-224005
AAV-h-SOST-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SOST (sclerostin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDD; DAND6; SOST1; VBCH
Description (Vector)
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Gene ID
50964
Gene Name (Vector)
sclerostin
Gene Symbol
SOST
HGNC ID
HGNC:13771
ORF Size (aa)
642
RefSeq ID
NM_025237
RefSeq Synonyms
NM_025237, BC101089, BC101088, BC101087, BC101086,
Species
human
UniGene ID
Hs.349204
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.