human SORBS2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SORBS2.
shAAV-223990
AAV-h-SORBS2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SORBS2 (sorbin and SH3 domain containing 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARGBP2; PRO0618
Description (Vector)
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
8470
Gene Name (Vector)
sorbin and SH3 domain containing 2
Gene Symbol
SORBS2
HGNC ID
HGNC:24098
ORF Size (aa)
1938
ORF Size (bp)
1938 bp
RefSeq ID
NM_003603
RefSeq Synonyms
NM_021069, NM_003603, NM_001270771, NM_001145675, NM_001145674, NM_001145673, NM_001145672, NM_001145671, NM_001145670, BC011883,
Species
human
UniGene ID
Hs.655143
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.