human SMAD7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SMAD7.
shAAV-223695
AAV-h-SMAD7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SMAD7 (SMAD family member 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CRCS3; MADH7; MADH8
Description (Vector)
SMAD7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
4092
Gene Name (Vector)
SMAD family member 7
Gene Symbol
SMAD7
HGNC ID
HGNC:6773
ORF Size (aa)
1281
ORF Size (bp)
1281 bp
RefSeq ID
NM_005904
RefSeq Synonyms
NM_005904, NM_001190823, NM_001190822, NM_001190821, BC074819, BC074818,
Species
human
UniGene ID
Hs.465087
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.