human SLC8A1 shRNA silencing AAV

Name
AAV-h-SLC8A1-shRNA

Cat No
shAAV-223607

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SLC8A1.

shAAV-223607

AAV-h-SLC8A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC8A1 (solute carrier family 8 member A1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NCX1

Description (Vector)

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.(supplied by OMIM, Apr 2004)

Gene ID

6546

Gene Name (Vector)

solute carrier family 8 member A1

Gene Symbol

SLC8A1

HGNC ID

HGNC:11068

ORF Size (aa)

2919

ORF Size (bp)

2919 bp

RefSeq ID

NM_021097

RefSeq Synonyms

NM_021097, NM_001252624, NM_001112802, NM_001112801, NM_001112800, BC172488, BC156359,

Species

human

UniGene ID

Hs.656261

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.