human SLC25A19 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SLC25A19.
shAAV-223231
AAV-h-SLC25A19-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SLC25A19 (solute carrier family 25 member 19). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNC; MCPHA; MUP1; THMD3; THMD4; TPC
Description (Vector)
SLC25A19 encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Gene ID
60386
Gene Name (Vector)
solute carrier family 25 member 19
Gene Symbol
SLC25A19
HGNC ID
HGNC:14409
ORF Size (aa)
963
RefSeq ID
NM_021734
RefSeq Synonyms
NM_021734, NM_001126122, NM_001126121, BC005120, BC001075,
Species
human
UniGene ID
Hs.514470
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.