human SLC12A7 shRNA silencing AAV

Name 
AAV-h-SLC12A7-shRNA
Cat No 
shAAV-223095
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SLC12A7.

shAAV-223095
AAV-h-SLC12A7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC12A7 (solute carrier family 12 member 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
electroneutral potassium-chloride cotransporter 4; KCC4; K-Cl cotransporter 4; potassium/chloride transporter KCC4; solute carrier family 12 (potassium/chloride transporter), member 7; solute carrier family 12 (potassium/chloride transporters), member 7; solute carrier family 12 member 7; SUCO/SLC12A7 fusion
Description (eCommerce)
K-Cl cotransporter 4 (KCC4) mediates electroneutral potassium-chloride cotransport when activated by cell swelling. KCC4 may mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. KCC4 is important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. It may be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y666].
Gene ID
10723
Gene Name (eCommerce)
solute carrier family 12 member 7
Gene Name (Vector)
solute carrier family 12 member 7
Gene Symbol
SLC12A7
HGNC ID
HGNC:10915
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3252
ORF Size (bp)
3252 bp
Protein Name (eCommerce)
Solute carrier family 12 member 7
RefSeq ID
NM_006598
RefSeq Synonyms
NM_006598, BC098390,
Research Areas
EGFR Signaling,Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
K-Cl cotransporter 4 (KCC4) mediates electroneutral potassium-chloride cotransport when activated by cell swelling. KCC4 may mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. KCC4 is important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. It may be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y666].
UniGene ID
Hs.172613
UniProt ID (eCommerce)
Q9Y666

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.