human SLC10A2 shRNA silencing AAV

Name 
AAV-h-SLC10A2-shRNA
Cat No 
shAAV-223072
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SLC10A2.

shAAV-223072
AAV-h-SLC10A2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC10A2 (solute carrier family 10 member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ASBT; IBAT; ISBT; NTCP2; PBAM
Description (Vector)
SLC10A2 encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG).
Gene ID
6555
Gene Name (Vector)
solute carrier family 10 member 2
Gene Symbol
SLC10A2
HGNC ID
HGNC:10906
ORF Size (aa)
1047
RefSeq ID
NM_000452
RefSeq Synonyms
NM_000452, BC130523, BC130521,
Species
human
UniGene ID
Hs.194783

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.