human SGCA shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SGCA.
shAAV-222840
AAV-h-SGCA-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SGCA (sarcoglycan alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
50DAG; adhalin; ADL; DAG2; DMDA2; LGMD2D; SCARMD1
Description (Vector)
SGCA encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6442
Gene Name (Vector)
sarcoglycan alpha
Gene Symbol
SGCA
HGNC ID
HGNC:10805
ORF Size (aa)
1164
ORF Size (bp)
1164 bp
RefSeq ID
NM_000023
RefSeq Synonyms
NM_001135697, NM_000023, BC025702,
Species
human
UniGene ID
Hs.463412
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.