human SERPINC1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SERPINC1.
shAAV-222702
AAV-h-SERPINC1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SERPINC1 (serpin family C member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AT3; AT3D; ATIII; THPH7
Description (Vector)
SERPINC1 is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Gene ID
462
Gene Name (Vector)
serpin family C member 1
Gene Symbol
SERPINC1
HGNC ID
HGNC:775
ORF Size (aa)
780
RefSeq ID
NM_000488
RefSeq Synonyms
NM_000488, BC022309,
Species
human
UniGene ID
Hs.75599
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.