human SEPT4 shRNA silencing AAV

Name
AAV-h-SEPT4-shRNA

Cat No
shAAV-222606

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SEPT4.

shAAV-222606

AAV-h-SEPT4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SEPT4 (septin 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARTS; BRADEION; CE5B3; H5; hCDCREL-2; hucep-7; MART; PNUTL2; SEP4

Description (Vector)

4-Sep is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. 4-Sep is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.

Gene ID

5414

Gene Name (Vector)

septin 4

Gene Symbol

4-Sep

HGNC ID

HGNC:9165

ORF Size (aa)

1380

ORF Size (bp)

1380 bp

RefSeq ID

NM_004574

RefSeq Synonyms

NM_080416, NM_080415, NM_004574, NM_001256822, NM_001256782, NM_001198713, BC018056,

Species

human

UniGene ID

Hs.287518

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.