human SEPT11 shRNA silencing AAV

Name 
AAV-h-SEPT11-shRNA
Cat No 
shAAV-222598
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SEPT11.

shAAV-222598
AAV-h-SEPT11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SEPT11 (septin 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; septin-11
Description (eCommerce)
Septin 11 is a filament-forming cytoskeletal GTPase. Septin 11 may play a role in cytokinesis (Potential). It also may play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NVA2].
Description (Vector)
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 (PubMed 15196925); Nagata et al., 2004 (PubMed 15485874)).(supplied by OMIM, Jul 2009)
Gene ID
55752
Gene Name (eCommerce)
septin 11
Gene Name (Vector)
septin 11
Gene Symbol
11-Sep
HGNC ID
HGNC:25589
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1290
ORF Size (bp)
1290 bp
Protein Name (eCommerce)
Septin-11
RefSeq ID
NM_018243
RefSeq Synonyms
NM_018243, NM_001306147, BC063615, BC008083,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Synapse
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,neurobiology
Species
human
Target Sentence
Septin 11 is a filament-forming cytoskeletal GTPase. Septin 11 may play a role in cytokinesis (Potential). It also may play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NVA2].
UniGene ID
Hs.128199
UniProt ID (eCommerce)
Q9NVA2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.