human SEPP1 shRNA silencing AAV

Name
AAV-h-SEPP1-shRNA

Cat No
shAAV-222588

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SELENOP.

shAAV-222588

AAV-h-SEPP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SELENOP (selenoprotein P). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SELP; SeP; SEPP; SEPP1

Description (Vector)

SEPP1 encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.

Gene ID

6414

Gene Name (Vector)

selenoprotein P

Gene Symbol

SELENOP

HGNC ID

HGNC:10751

ORF Size (aa)

1146

ORF Size (bp)

1146 bp

RefSeq ID

NM_005410

RefSeq Synonyms

NM_005410, NM_001093726, NM_001085486, BC058919, BC046152, BC040075, BC015875,

Species

human

UniGene ID

Hs.718521

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.