human SEPP1 shRNA silencing AAV

Name 
AAV-h-SEPP1-shRNA
Cat No 
shAAV-222588
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SELENOP.

shAAV-222588
AAV-h-SEPP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SELENOP (selenoprotein P). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SELP; SeP; SEPP; SEPP1
Description (Vector)
SEPP1 encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.
Gene ID
6414
Gene Name (Vector)
selenoprotein P
Gene Symbol
SELENOP
HGNC ID
HGNC:10751
ORF Size (aa)
1146
ORF Size (bp)
1146 bp
RefSeq ID
NM_005410
RefSeq Synonyms
NM_005410, NM_001093726, NM_001085486, BC058919, BC046152, BC040075, BC015875,
Species
human
UniGene ID
Hs.718521

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.