human SEC62 shRNA silencing AAV

Name 
AAV-h-SEC62-shRNA
Cat No 
shAAV-222507
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SEC62.

shAAV-222507
AAV-h-SEC62-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SEC62 (SEC62 homolog, preprotein translocation factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
98
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Dtrp1; HTP1; hTP-1; membrane protein SEC62, S.cerevisiae, homolog of; SEC62 preprotein translocation factor; TLOC1; TP-1; translocation protein 1; translocation protein SEC62
Description (eCommerce)
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Sec62 and Sec63 protein are found to be associated with ribosome-free Sec61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Sec62 is an integral membrane protein located in the rough ER [taken from NCBI Entrez Gene (Gene ID: 7095)].
Description (Vector)
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Gene ID
7095
Gene Name (eCommerce)
SEC62 homolog, preprotein translocation factor
Gene Name (Vector)
SEC62 homolog, preprotein translocation factor
Gene Symbol
SEC62
HGNC ID
HGNC:11846
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1200
Protein Name (eCommerce)
Translocation protein SEC62
RefSeq ID
NM_003262
RefSeq Synonyms
NM_003262, BC012035,
Research Areas
Cytoskeleton,Immunology,Metabolism/Metabolic Process,Translational Control,Transport
Research Areas (Faceted)
cell_biology,immunology,metabolism,transcription_translation
Species
human
Target Sentence
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Sec62 and Sec63 protein are found to be associated with ribosome-free Sec61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Sec62 is an integral membrane protein located in the rough ER [taken from NCBI Entrez Gene (Gene ID: 7095)].
UniGene ID
Hs.622596
UniProt ID (eCommerce)
Q99442

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.