human SEC24B shRNA silencing AAV

Name 
AAV-h-SEC24B-shRNA
Cat No 
shAAV-222488
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SEC24B.

shAAV-222488
AAV-h-SEC24B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SEC24B (SEC24 homolog B, COPII coat complex component). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
protein transport protein Sec24B; SEC24; SEC24 related gene family, member B; SEC24-related protein B; secretory protein 24
Description (eCommerce)
SEC24B is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. SEC24B has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role SEC24B is implicated in the shaping of the vesicle, and also in cargo selection and concentration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95487].
Description (Vector)
SEC24B is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
10427
Gene Name (eCommerce)
SEC24 homolog B, COPII coat complex component
Gene Name (Vector)
SEC24 homolog B, COPII coat complex component
Gene Symbol
SEC24B
HGNC ID
HGNC:10704
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3807
ORF Size (bp)
3807 bp
Protein Name (eCommerce)
Protein transport protein Sec24B
RefSeq ID
NM_006323
RefSeq Synonyms
NM_006323, NM_001318086, NM_001318085, NM_001300813, NM_001042734, BC143276, BC143268, BC117135, BC040137,
Research Areas
Antigen Processing and Presentation,Golgi Apparatus,Immunology,Metabolism/Metabolic Process,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,immunology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
SEC24B is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. SEC24B has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role SEC24B is implicated in the shaping of the vesicle, and also in cargo selection and concentration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95487].
UniGene ID
Hs.292472
UniProt ID (eCommerce)
O95487

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.