human SDC1 shRNA silencing AAV

Name
AAV-h-SDC1-shRNA

Cat No
shAAV-222412

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SDC1.

shAAV-222412

AAV-h-SDC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SDC1 (syndecan 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD antigen CD138;CD138;CD138 antigen;heparan sulfate proteoglycan fibroblast growth factor receptor;SDC;SYND1;syndecan;syndecan proteoglycan 1;syndecan-1

Description (Vector)

SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

Gene ID

6382

Gene Name (eCommerce)

syndecan 1

Gene Name (Vector)

syndecan 1

Gene Symbol

SDC1

HGNC ID

HGNC:10658

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

933

Protein Name (eCommerce)

Syndecan-1

RefSeq ID

NM_002997

RefSeq Synonyms

NM_002997, NM_001006946, BC008765,

Research Areas

Angiogenesis,Cancer,Cytoskeleton,EGFR Signaling,Golgi Apparatus,Metabolism/Metabolic Process,Neurobiology,Signal Transduction,Wnt Signaling

Research Areas (Faceted)

cell_biology,metabolism,cancer

Species

human

UniGene ID

Hs.665958

UniProt ID (eCommerce)

P18827

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.