human SCN5A shRNA silencing AAV

Name 
AAV-h-SCN5A-shRNA
Cat No 
shAAV-222374
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SCN5A.

shAAV-222374
AAV-h-SCN5A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SCN5A (sodium voltage-gated channel alpha subunit 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1
Description (Vector)
SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
Gene ID
6331
Gene Name (Vector)
sodium voltage-gated channel alpha subunit 5
Gene Symbol
SCN5A
HGNC ID
HGNC:10593
ORF Size (aa)
5952
ORF Size (bp)
5952 bp
RefSeq ID
NM_000335
RefSeq Synonyms
NM_198056, NM_001160161, NM_001160160, NM_001099405, NM_001099404, NM_000335, BC144621, BC140813,
Species
human
UniGene ID
Hs.517898

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.