human SCN1B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SCN1B.
shAAV-222367
AAV-h-SCN1B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SCN1B (sodium voltage-gated channel beta subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATFB13; BRGDA5; GEFSP1
Description (Vector)
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6324
Gene Name (Vector)
sodium voltage-gated channel beta subunit 1
Gene Symbol
SCN1B
HGNC ID
HGNC:10586
ORF Size (aa)
657
RefSeq ID
NM_001037
RefSeq Synonyms
NM_199037, NM_001321605, NM_001037, BC112922, BC067122, BC021266,
Species
human
UniGene ID
Hs.436646
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.