human SCARB2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SCARB2.
shAAV-222317
AAV-h-SCARB2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SCARB2 (scavenger receptor class B member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SR-BII
Description (Vector)
SCARB2 is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
950
Gene Name (Vector)
scavenger receptor class B member 2
Gene Symbol
SCARB2
HGNC ID
HGNC:1665
ORF Size (aa)
1437
ORF Size (bp)
1437 bp
RefSeq ID
NM_005506
RefSeq Synonyms
NM_005506, NM_001204255, BC021892,
Species
human
UniGene ID
Hs.349656
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.