human SAPS3 shRNA silencing AAV

Name 
AAV-h-SAPS3-shRNA
Cat No 
shAAV-222247
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PPP6R3.

shAAV-222247
AAV-h-SAPS3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PPP6R3 (protein phosphatase 6 regulatory subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
54
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C11orf23; PP6R3; SAP190; SAPL; SAPLa; SAPS domain family member 3; SAPS domain family, member 3; SAPS3; serine/threonine-protein phosphatase 6 regulatory subunit 3; sporulation-induced transcript 4-associated protein SAPL
Description (eCommerce)
SAPS3 is a regulatory subunit of the PP6 phosphatase. There are 3 human SAPs (sit4-associated proteins), SAPS1, SAPS2, and SAPS3. The human SAPs are related to SAPs found in yeast that associate with the sit4 phosphatase which is the homolog of human PP6 phosphatase. In yeast sit4 and its associated SAPs are involved in a variety of processes which include transcription, translation, bud formation, glycogen metabolism, ion homeostasis, and telomere function. Because the SAPS3 gene maps to the IDDM4 locus at 11q13, SAPS3 has been implicated in insulin-dependent diabetes mellitus. SAPS domain family member 3, protein phosphatase 6 regulatory subunit 3, PP6R3, and KIAA1558.
Description (Vector)
Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 (PubMed 16769727)).(supplied by OMIM, Nov 2010)
Gene ID
55291
Gene Name (eCommerce)
protein phosphatase 6 regulatory subunit 3
Gene Name (Vector)
protein phosphatase 6 regulatory subunit 3
Gene Symbol
PPP6R3
HGNC ID
HGNC:1173
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2535
ORF Size (bp)
2535 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 6 regulatory subunit 3
RefSeq ID
NM_018312
RefSeq Synonyms
NM_018312, NM_001164164, NM_001164163, NM_001164162, NM_001164161, NM_001164160, BC107599, BC105934, BC105933,
Research Areas
Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
SAPS3 is a regulatory subunit of the PP6 phosphatase. There are 3 human SAPs (sit4-associated proteins), SAPS1, SAPS2, and SAPS3. The human SAPs are related to SAPs found in yeast that associate with the sit4 phosphatase which is the homolog of human PP6 phosphatase. In yeast sit4 and its associated SAPs are involved in a variety of processes which include transcription, translation, bud formation, glycogen metabolism, ion homeostasis, and telomere function. Because the SAPS3 gene maps to the IDDM4 locus at 11q13, SAPS3 has been implicated in insulin-dependent diabetes mellitus. SAPS domain family member 3, protein phosphatase 6 regulatory subunit 3, PP6R3, and KIAA1558.
UniGene ID
Hs.503022
UniProt ID (eCommerce)
Q5H9R7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.