human RSPO1 shRNA silencing AAV

Name
AAV-h-RSPO1-shRNA

Cat No
shAAV-222063

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RSPO1.

shAAV-222063

AAV-h-RSPO1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RSPO1 (R-spondin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CRISTIN3; RSPO

Description (Vector)

RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.

Gene ID

284654

Gene Name (Vector)

R-spondin 1

Gene Symbol

RSPO1

HGNC ID

HGNC:21679

ORF Size (aa)

792

RefSeq ID

NM_001038633

RefSeq Synonyms

NM_001242910, NM_001242909, NM_001242908, NM_001038633, BC114966,

Species

human

UniGene ID

Hs.135015

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.