human RRM2B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RRM2B.
shAAV-222005
AAV-h-RRM2B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MTDPS8A; MTDPS8B; P53R2
Description (Vector)
RRM2B encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
Gene ID
50484
Gene Name (Vector)
ribonucleotide reductase regulatory TP53 inducible subunit M2B
Gene Symbol
RRM2B
HGNC ID
HGNC:17296
ORF Size (aa)
1056
ORF Size (bp)
1056 bp
RefSeq ID
NM_015713
RefSeq Synonyms
NM_015713, NM_001172478, NM_001172477, BC130628, BC117496, BC108261,
Species
human
UniGene ID
Hs.512592
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.