human RPS6KB2 shRNA silencing AAV

Name
AAV-h-RPS6KB2-shRNA

Cat No
shAAV-221944

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RPS6KB2.

shAAV-221944

AAV-h-RPS6KB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPS6KB2 (ribosomal protein S6 kinase B2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

70 kDa ribosomal protein S6 kinase 2; KLS; p70 ribosomal S6 kinase beta; p70 S6 kinase beta; p70 S6KB; p70 S6K-beta; p70(S6K)-beta; P70-beta; P70-beta-1; P70-beta-2; p70-S6K 2; P70S6K2; p70S6Kb; ribosomal protein S6 kinase beta-2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; S6 kinase-related kinase; S6K2; S6KB; S6Kbeta; S6K-beta; S6K-beta2; S6K-beta-2; S6KI(2); serine/threonine-protein kinase 14 beta; serine/threonine-protein kinase 14B; SRK; STK14B

Description (eCommerce)

Ribosomal protein S6 kinase beta 2 (S6K2) encodes a member of the ribosomal S6 kinase family that phosphorylates the 40 S ribosomal subunit protein S6 and eukaryotic translation initiation factor 4B (eIF4B). S6K2 is an isoform of the p70 S6 kinase, S6K (p70a/S6K1) and is in the PI3K and mTOR pathway.

Description (Vector)

RPS6KB2 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

Gene ID

6199

Gene Name (eCommerce)

ribosomal protein S6 kinase B2

Gene Name (Vector)

ribosomal protein S6 kinase B2

Gene Symbol

RPS6KB2

HGNC ID

HGNC:10437

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1449

ORF Size (bp)

1449 bp

Protein Name (eCommerce)

Ribosomal protein S6 kinase beta-2

RefSeq ID

NM_003952

RefSeq Synonyms

NM_003952, BC136564, BC006106, BC000094,

Research Areas

B-cell Receptor Signaling,Breast Cancer,Cancer,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,HIF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leukemia,mTOR Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,Translational Control,VEGF Signaling

Research Areas (Faceted)

cancer,cell_biology,immunology,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.534345

UniProt ID (eCommerce)

Q9UBS0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.