human RPN1 shRNA silencing AAV

Name 
AAV-h-RPN1-shRNA
Cat No 
shAAV-221787
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RPN1.

shAAV-221787
AAV-h-RPN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPN1 (ribophorin I). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; oligosaccharyltransferase 1 homolog; oligosaccharyltransferase complex subunit (non-catalytic); OST1; RBPH1; Ribophorin I; ribophorin-1; RPN-I
Description (eCommerce)
Ribophorin I is an essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains [taken from NCBI Entrez Gene (Gene ID: 6184)].
Description (Vector)
RPN1 encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome.
Gene ID
6184
Gene Name (eCommerce)
ribophorin I
Gene Name (Vector)
ribophorin I
Gene Symbol
RPN1
HGNC ID
HGNC:10381
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1824
ORF Size (bp)
1824 bp
Protein Name (eCommerce)
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
RefSeq ID
NM_002950
RefSeq Synonyms
NM_002950, BC010839,
Research Areas
Complexome,Gene Expression,Metabolism/Metabolic Process,Proteasome,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Ribophorin I is an essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains [taken from NCBI Entrez Gene (Gene ID: 6184)].
UniGene ID
Hs.603636
UniProt ID (eCommerce)
P04843

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.