human ROCK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ROCK2.
shAAV-221476
AAV-h-ROCK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ROCK2 (Rho associated coiled-coil containing protein kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
p164 ROCK-2; Rho kinase 2; rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; ROCK-II
Description (eCommerce)
Rho-associated protein kinase 2 (ROCK2), or Rho kinase alpha, is a serine-threonine protein kinase that plays an important role in cellular apoptosis, growth, cell motility and cell contraction. ROCK2 shares an overall 65% homology in amino acid sequence with ROCK1. The ROCK1 and ROCK2 isoforms are products of two separate genes. Both ROCK1 and ROCK2 are downstream targets of the Rho A small GTP-binding protein. As downstream effectors of RhoA, ROCK1 and ROCK2 mediate changes in the actin cytoskeleton via phosphorylation of target proteins such as the MBS subunit of MLCP, MLC, ERM proteins, protein LIM kinase and adducin.
Description (Vector)
ROCK2 is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Gene ID
9475
Gene Name (eCommerce)
Rho associated coiled-coil containing protein kinase 2
Gene Name (Vector)
Rho associated coiled-coil containing protein kinase 2
Gene Symbol
ROCK2
HGNC ID
HGNC:10252
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2112
ORF Size (bp)
2112 bp
Protein Name (eCommerce)
Rho-associated protein kinase 2
RefSeq ID
NM_004850
RefSeq Synonyms
NM_004850, NM_001321643, BC111801,
Research Areas
Angiogenesis,Axon Guidance,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Cytoskeleton,Estrogen Signaling,GPCR Signaling,Immunology,Kinase/Phosphatase,Neurobiology,Neurodevelopment,PLK1 Signaling,Rho Signaling,Signal Transduction,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Rho-associated protein kinase 2 (ROCK2), or Rho kinase alpha, is a serine-threonine protein kinase that plays an important role in cellular apoptosis, growth, cell motility and cell contraction. ROCK2 shares an overall 65% homology in amino acid sequence with ROCK1. The ROCK1 and ROCK2 isoforms are products of two separate genes. Both ROCK1 and ROCK2 are downstream targets of the Rho A small GTP-binding protein. As downstream effectors of RhoA, ROCK1 and ROCK2 mediate changes in the actin cytoskeleton via phosphorylation of target proteins such as the MBS subunit of MLCP, MLC, ERM proteins, protein LIM kinase and adducin.
UniGene ID
Hs.591600
UniProt ID (eCommerce)
O75116
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.