human RNF8 shRNA silencing AAV

Name
AAV-h-RNF8-shRNA

Cat No
shAAV-221441

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RNF8.

shAAV-221441

AAV-h-RNF8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RNF8 (ring finger protein 8). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

hRNF8

Description (Vector)

RNF8 contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

Gene ID

9025

Gene Name (Vector)

ring finger protein 8

Gene Symbol

RNF8

HGNC ID

HGNC:10071

ORF Size (aa)

1458

ORF Size (bp)

1458 bp

RefSeq ID

NM_003958

RefSeq Synonyms

NM_183078, NM_003958, BC007517,

Species

human

UniGene ID

Hs.485278

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.