human RNF128 shRNA silencing AAV

Name
AAV-h-RNF128-shRNA

Cat No
shAAV-221344

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RNF128.

shAAV-221344

AAV-h-RNF128-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RNF128 (ring finger protein 128, E3 ubiquitin protein ligase). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GRAIL

Description (Vector)

RNF128 is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene ID

79589

Gene Name (Vector)

ring finger protein 128, E3 ubiquitin protein ligase

Gene Symbol

RNF128

HGNC ID

HGNC:21153

ORF Size (aa)

1287

ORF Size (bp)

1287 bp

RefSeq ID

NM_024539

RefSeq Synonyms

NM_194463, NM_024539, BC063404,

Species

human

UniGene ID

Hs.496542

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.