human RMI1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RMI1.
shAAV-221280
AAV-h-RMI1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RMI1 (RecQ mediated genome instability 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BLAP75; BLM-associated polypeptide, 75 kDa; BLM-associated protein 75 kDa; BLM-associated protein of 75 kDa; C9orf76; FAAP75; homolog of yeast RecQ-mediated genome instability 1 (RMI1); recQ-mediated genome instability protein 1; RMI1, RecQ mediated genome instability 1, homolog
Description (eCommerce)
BLM-associated polypeptide, 75 kDa (BLAP75) is a component of a dissolvasome complex that contains BLM (Bloom syndrome protein) and TopoIII-alpha and functions to dissolve double Holliday junctions and suppress DNA crossover formation in mitotic cells.
Description (Vector)
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 (PubMed 16595695)).(supplied by OMIM, Mar 2008)
Gene ID
80010
Gene Name (eCommerce)
RecQ mediated genome instability 1
Gene Name (Vector)
RecQ mediated genome instability 1
Gene Symbol
RMI1
HGNC ID
HGNC:25764
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1140
ORF Size (bp)
1140 bp
Protein Name (eCommerce)
RecQ-mediated genome instability protein 1
RefSeq ID
NM_024945
RefSeq Synonyms
NM_024945, BC064937, BC039999,
Research Areas
DNA Damage/Repair,DNA Replication,Fanconi anemia
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
BLM-associated polypeptide, 75 kDa (BLAP75) is a component of a dissolvasome complex that contains BLM (Bloom syndrome protein) and TopoIII-alpha and functions to dissolve double Holliday junctions and suppress DNA crossover formation in mitotic cells.
UniGene ID
Hs.284137
UniProt ID (eCommerce)
Q9H9A7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.