human RET shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RET.
shAAV-221016
AAV-h-RET-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RET (ret proto-oncogene). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51
Description (Vector)
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Gene ID
5979
Gene Name (Vector)
ret proto-oncogene
Gene Symbol
RET
HGNC ID
HGNC:9967
ORF Size (aa)
3219
ORF Size (bp)
3219 bp
RefSeq ID
NM_020630
RefSeq Synonyms
NM_020975, NM_020630, BC004257, BC003072,
Species
human
UniGene ID
Hs.350321
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.