human REN shRNA silencing AAV

Name
AAV-h-REN-shRNA

Cat No
shAAV-221004

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human REN.

shAAV-221004

AAV-h-REN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human REN (renin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HNFJ2

Description (Vector)

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.

Gene ID

5972

Gene Name (Vector)

renin

Gene Symbol

REN

HGNC ID

HGNC:9958

ORF Size (aa)

1221

ORF Size (bp)

1221 bp

RefSeq ID

NM_000537

RefSeq Synonyms

NM_000537, BC047752, BC033474,

Species

human

UniGene ID

Hs.3210

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.