human REN shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human REN.
shAAV-221004
AAV-h-REN-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human REN (renin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HNFJ2
Description (Vector)
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Gene ID
5972
Gene Name (Vector)
renin
Gene Symbol
REN
HGNC ID
HGNC:9958
ORF Size (aa)
1221
ORF Size (bp)
1221 bp
RefSeq ID
NM_000537
RefSeq Synonyms
NM_000537, BC047752, BC033474,
Species
human
UniGene ID
Hs.3210
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.