human RECQL5 shRNA silencing AAV

Name
AAV-h-RECQL5-shRNA

Cat No
shAAV-220976

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RECQL5.

shAAV-220976

AAV-h-RECQL5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RECQL5 (RecQ like helicase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATP-dependent DNA helicase Q5; DNA helicase, RecQ-like type 5; RecQ helicase-like 5; RecQ protein-like 5; RECQ5

Description (eCommerce)

RECQ5 is one of five human homologs of RecQ DNA helicases. RecQ helicases function in DNA replication and repair and are important to genomic stability. Mutations in the genes encoding BLM (RECQL2), WRN (RECQL3), and RECQL4 result in a predisposition to cancer. No heritable disease has been found to be associated with RECQL5.

Description (Vector)

RECQL5 is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene.

Gene ID

9400

Gene Name (eCommerce)

RecQ like helicase 5

Gene Name (Vector)

RecQ like helicase 5

Gene Symbol

RECQL5

HGNC ID

HGNC:9950

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2895

ORF Size (bp)

2895 bp

Protein Name (eCommerce)

ATP-dependent DNA helicase Q5

RefSeq ID

NM_001003715

RefSeq Synonyms

NM_004259, NM_001003716, NM_001003715, BC063440,

Research Areas

Cell Cycle,Cell Division,DNA Damage/Repair,DNA Replication,Helicase Activity

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

RECQ5 is one of five human homologs of RecQ DNA helicases. RecQ helicases function in DNA replication and repair and are important to genomic stability. Mutations in the genes encoding BLM (RECQL2), WRN (RECQL3), and RECQL4 result in a predisposition to cancer. No heritable disease has been found to be associated with RECQL5.

UniGene ID

Hs.632229

UniProt ID (eCommerce)

O94762

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.