human RBPJ shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RBPJ.
shAAV-220921
AAV-h-RBPJ-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AOS3; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH
Description (Vector)
RBPJ is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.
Gene ID
3516
Gene Name (Vector)
recombination signal binding protein for immunoglobulin kappa J region
Gene Symbol
RBPJ
HGNC ID
HGNC:5724
ORF Size (aa)
1458
ORF Size (bp)
1458 bp
RefSeq ID
NM_005349
RefSeq Synonyms
NM_203284, NM_203283, NM_015874, NM_005349, BC064976, BC020780,
Species
human
UniGene ID
Hs.479396
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.