human RAPGEF6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RAPGEF6.
shAAV-220740
AAV-h-RAPGEF6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RAPGEF6 (Rap guanine nucleotide exchange factor 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KIA001LB; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ domain-containing guanine nucleotide exchange factor I; PDZGEF2; PDZ-GEF2; RAGEF2; RA-GEF-2; Rap guanine nucleotide exchange factor (GEF) 6; rap guanine nucleotide exchange factor 6
Description (eCommerce)
PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions.
Gene ID
51735
Gene Name (eCommerce)
Rap guanine nucleotide exchange factor 6
Gene Name (Vector)
Rap guanine nucleotide exchange factor 6
Gene Symbol
RAPGEF6
HGNC ID
HGNC:20655
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2484
ORF Size (bp)
2484 bp
Protein Name (eCommerce)
Rap guanine nucleotide exchange factor 6
RefSeq ID
NM_016340
RefSeq Synonyms
NM_016340, NM_001164390, NM_001164389, NM_001164388, NM_001164387, NM_001164386, BC144627, BC142964, BC140820, BC133703,
Research Areas
Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology
Species
human
Target Sentence
PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions.
UniGene ID
Hs.483329
UniProt ID (eCommerce)
Q8TEU7
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.