human RAET1E shRNA silencing AAV

Name
AAV-h-RAET1E-shRNA

Cat No
shAAV-220664

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RAET1E.

shAAV-220664

AAV-h-RAET1E-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RAET1E (retinoic acid early transcript 1E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bA350J20.7; LETAL; N2DL-4; NKG2DL4; RAET1E2; RL-4; ULBP4

Description (Vector)

RAET1E belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

135250

Gene Name (Vector)

retinoic acid early transcript 1E

Gene Symbol

RAET1E

HGNC ID

HGNC:16793

ORF Size (aa)

792

RefSeq ID

NM_139165

RefSeq Synonyms

NM_139165, NM_001243328, NM_001243327, NM_001243325, BC103694,

Species

human

UniGene ID

Hs.511818

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.