human QPRT shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human QPRT.
shAAV-220469
AAV-h-QPRT-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human QPRT (quinolinate phosphoribosyltransferase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HEL-S-90n; QPRTase
Description (Vector)
QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
Gene ID
23475
Gene Name (Vector)
quinolinate phosphoribosyltransferase
Gene Symbol
QPRT
HGNC ID
HGNC:9755
ORF Size (aa)
894
RefSeq ID
NM_014298
RefSeq Synonyms
NM_014298, NM_001318250, NM_001318249, BC018910, BC010033, BC005060,
Species
human
UniGene ID
Hs.513484
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.