human PTPRR shRNA silencing AAV

Name
AAV-h-PTPRR-shRNA

Cat No
shAAV-220359

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PTPRR.

shAAV-220359

AAV-h-PTPRR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPRR (protein tyrosine phosphatase, receptor type R). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ

Description (Vector)

PTPRR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12.

Gene ID

5801

Gene Name (Vector)

protein tyrosine phosphatase, receptor type R

Gene Symbol

PTPRR

HGNC ID

HGNC:9680

ORF Size (aa)

1239

ORF Size (bp)

1239 bp

RefSeq ID

NM_002849

RefSeq Synonyms

NM_130846, NM_002849, NM_001207016, NM_001207015, BC122866, BC119777, BC110900,

Species

human

UniGene ID

Hs.506076

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.