human PTPN22 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PTPN22.
shAAV-220320
AAV-h-PTPN22-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PTPN22 (protein tyrosine phosphatase, non-receptor type 22). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LYP; LYP1; LYP2; PEP; PTPN8
Description (Vector)
PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Gene ID
26191
Gene Name (Vector)
protein tyrosine phosphatase, non-receptor type 22
Gene Symbol
PTPN22
HGNC ID
HGNC:9652
ORF Size (aa)
2259
ORF Size (bp)
2259 bp
RefSeq ID
NM_012411
RefSeq Synonyms
NM_015967, NM_012411, NM_001308297, NM_001193431, BC071670, BC017785,
Species
human
UniGene ID
Hs.535276
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.