human PTCH2 shRNA silencing AAV

Name
AAV-h-PTCH2-shRNA

Cat No
shAAV-220215

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PTCH2.

shAAV-220215

AAV-h-PTCH2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTCH2 (patched 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PTC2

Description (Vector)

PTCH2 encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.

Gene ID

8643

Gene Name (Vector)

patched 2

Gene Symbol

PTCH2

HGNC ID

HGNC:9586

ORF Size (aa)

3609

ORF Size (bp)

3609 bp

RefSeq ID

NM_003738

RefSeq Synonyms

NM_003738, NM_001166292, BC152911,

Species

human

UniGene ID

Hs.591497

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.