human PSMD3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PSMD3.
shAAV-220158
AAV-h-PSMD3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PSMD3 (proteasome 26S subunit, non-ATPase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; P58; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; proteasome subunit p58; RPN3; S3; tissue specific transplantation antigen 2; TSTA2
Description (eCommerce)
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 (PSMD3) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMD3 is a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid [taken from NCBI Entrez Gene (Gene ID: 5709)].
Description (Vector)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count.
Gene ID
5709
Gene Name (eCommerce)
proteasome 26S subunit, non-ATPase 3
Gene Name (Vector)
proteasome 26S subunit, non-ATPase 3
Gene Symbol
PSMD3
HGNC ID
HGNC:9560
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1605
ORF Size (bp)
1605 bp
Protein Name (eCommerce)
26S proteasome non-ATPase regulatory subunit 3
RefSeq ID
NM_002809
RefSeq Synonyms
NM_002809, BC025686, BC020518, BC012302, BC004859, BC000074,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Cell Division,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,NF-kB Signaling,Notch Signaling,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,metabolism,neurobiology,signal_transduction,immunology,developmental_biology,neurobiology,cell_biology,genetics,transcription_translation,signal_transduction,immunology,genetics,developmental_biology
Species
human
Target Sentence
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 (PSMD3) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMD3 is a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid [taken from NCBI Entrez Gene (Gene ID: 5709)].
UniGene ID
Hs.12970
UniProt ID (eCommerce)
O43242
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.