human PSAP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PSAP.
shAAV-220053
AAV-h-PSAP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PSAP (prosaposin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GLBA; SAP1
Description (Vector)
PSAP encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
5660
Gene Name (Vector)
prosaposin
Gene Symbol
PSAP
HGNC ID
HGNC:9498
ORF Size (aa)
1575
ORF Size (bp)
1575 bp
RefSeq ID
NM_002778
RefSeq Synonyms
NM_002778, NM_001042466, NM_001042465, BC007612, BC004275, BC001503,
Species
human
UniGene ID
Hs.523004
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.