human PRODH shRNA silencing AAV

Name
AAV-h-PRODH-shRNA

Cat No
shAAV-219924

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PRODH.

shAAV-219924

AAV-h-PRODH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRODH (proline dehydrogenase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HSPOX2; PIG6; POX; PRODH1; PRODH2; TP53I6

Description (Vector)

PRODH encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). PRODH is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

5625

Gene Name (Vector)

proline dehydrogenase 1

Gene Symbol

PRODH

HGNC ID

HGNC:9453

ORF Size (aa)

1479

ORF Size (bp)

1479 bp

RefSeq ID

NM_016335

RefSeq Synonyms

NM_016335, NM_001195226, BC121809, BC118597,

Species

human

UniGene ID

Hs.517352

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.