human PROC shRNA silencing AAV

Name
AAV-h-PROC-shRNA

Cat No
shAAV-219921

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PROC.

shAAV-219921

AAV-h-PROC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PROC (protein C, inactivator of coagulation factors Va and VIIIa). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

APC; PC; PROC1; THPH3; THPH4

Description (Vector)

PROC encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene ID

5624

Gene Name (Vector)

protein C, inactivator of coagulation factors Va and VIIIa

Gene Symbol

PROC

HGNC ID

HGNC:9451

ORF Size (aa)

1386

ORF Size (bp)

1386 bp

RefSeq ID

NM_000312

RefSeq Synonyms

NM_000312, BC034377,

Species

human

UniGene ID

Hs.224698

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.