human PRIM2 shRNA silencing AAV

Name 
AAV-h-PRIM2-shRNA
Cat No 
shAAV-219827
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PRIM2.

shAAV-219827
AAV-h-PRIM2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRIM2 (primase (DNA) subunit 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DNA primase 58 kDa subunit; DNA primase large subunit; p58; PRIM2A; primase (DNA) subunit 2; primase, DNA, polypeptide 2 (58kDa)
Description (eCommerce)
PRIM2 is the 58 kilodalton large subunit of DNA primase. DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49643].
Description (Vector)
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.
Gene ID
5558
Gene Name (eCommerce)
DNA primase subunit 2
Gene Name (Vector)
primase (DNA) subunit 2
Gene Symbol
PRIM2
HGNC ID
HGNC:9370
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1530
ORF Size (bp)
1530 bp
Protein Name (eCommerce)
DNA primase large subunit
RefSeq ID
NM_000947
RefSeq Synonyms
NM_001282488, NM_001282487, NM_000947, BC064931,
Research Areas
Cell Cycle,DNA Damage/Repair,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
PRIM2 is the 58 kilodalton large subunit of DNA primase. DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49643].
UniGene ID
Hs.654580
UniProt ID (eCommerce)
P49643

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.