human PRAME shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PRAME.
shAAV-219709
AAV-h-PRAME-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PRAME (preferentially expressed antigen in melanoma). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CT130; MAPE; OIP-4; OIP4
Description (Vector)
PRAME encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Gene ID
23532
Gene Name (Vector)
preferentially expressed antigen in melanoma
Gene Symbol
PRAME
HGNC ID
HGNC:9336
ORF Size (aa)
1530
ORF Size (bp)
1530 bp
RefSeq ID
NM_206953
RefSeq Synonyms
NM_206956, NM_206955, NM_206954, NM_206953, NM_006115, NM_001318127, NM_001318126, NM_001291719, NM_001291717, NM_001291716, NM_001291715, BC039731, BC022008, BC014074,
Species
human
UniGene ID
Hs.30743
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.