human PPARGC1B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PPARGC1B.
shAAV-219515
AAV-h-PPARGC1B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PPARGC1B (PPARG coactivator 1 beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ERRL1; PERC; peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1(beta); PGC1B; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PPARgamma coactivator 1 beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta
Description (eCommerce)
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1beta) is a member of a family of transcriptional coactivators that play a role in metabolism and whole-body homeostasis. PGC-1beta has been shown to be a co-activator of the estrogen receptor alpha, glucocorticoid receptor, and the nuclear respiratory factor 1 (NRF1). Additionally PGC-1beta is suggested to be integral to mitochondrial function and glucose metabolism.
Description (Vector)
PPARGC1B stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
133522
Gene Name (eCommerce)
PPARG coactivator 1 beta
Gene Name (Vector)
PPARG coactivator 1 beta
Gene Symbol
PPARGC1B
HGNC ID
HGNC:30022
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2955
ORF Size (bp)
2955 bp
Protein Name (eCommerce)
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
RefSeq ID
NM_133263
RefSeq Synonyms
NM_133263, NM_001172699, NM_001172698, BC144251, BC132973, BC132971,
Research Areas
Estrogen Signaling,Metabolism/Metabolic Process,Mitochondrion,Nuclear Receptor Coactivators,RNA Binding,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1beta) is a member of a family of transcriptional coactivators that play a role in metabolism and whole-body homeostasis. PGC-1beta has been shown to be a co-activator of the estrogen receptor alpha, glucocorticoid receptor, and the nuclear respiratory factor 1 (NRF1). Additionally PGC-1beta is suggested to be integral to mitochondrial function and glucose metabolism.
UniGene ID
Hs.591261
UniProt ID (eCommerce)
Q86YN6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.