human POU6F2 shRNA silencing AAV

Name
AAV-h-POU6F2-shRNA

Cat No
shAAV-219490

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human POU6F2.

shAAV-219490

AAV-h-POU6F2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POU6F2 (POU class 6 homeobox 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RPF-1; WT5; WTSL

Description (Vector)

POU6F2 encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. POU6F2 is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene ID

11281

Gene Name (Vector)

POU class 6 homeobox 2

Gene Symbol

POU6F2

HGNC ID

HGNC:21694

ORF Size (aa)

2049

ORF Size (bp)

2049 bp

RefSeq ID

NM_007252

RefSeq Synonyms

NM_007252, NM_001166018, BC152915,

Species

human

UniGene ID

Hs.137106

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.