human POM121 shRNA silencing AAV

Name
AAV-h-POM121-shRNA

Cat No
shAAV-219432

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human POM121.

shAAV-219432

AAV-h-POM121-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POM121 (POM121 transmembrane nucleoporin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

P145; POM121A

Description (Vector)

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and multiple pseudogenes have been identified.

Gene ID

9883

Gene Name (Vector)

POM121 transmembrane nucleoporin

Gene Symbol

POM121

HGNC ID

HGNC:19702

ORF Size (aa)

2955

ORF Size (bp)

2955 bp

RefSeq ID

NM_172020

RefSeq Synonyms

NM_172020, NM_001257190, BC008794,

Species

human

UniGene ID

Hs.655217

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.